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RNA and Stem Cell Biology

BELLODI group

Our research

Ribonucleic acid or RNA, one of life’s indispensable molecules, governs the flow of the genetic information within cells. Our laboratory focuses new facets of gene expression control in stem and cancer cell at a molecular, cellular and organismal level. Using hematopoiesis as a model system to study stem cell function, we combine innovative genetic models with state-of-the-art genome-wide sequencing and proteomic techniques to investigate gene regulatory mechanisms that involve RNA epigenetic modifications, noncoding RNAs and RNA binding proteins during development and tumorigenesis.

Aims

  • Study the function of RNA epigenetic modifications in stem cells during normal and malignant hematopoiesis
  • Investigate the oncogenic programs driving aberrant mRNA splicing and translation in human cancers
  • Delineate the role of orphan small ribonucleoproteins (RNPs) for stem cell regulation during embryonic development and disease

Impact

The mechanisms that direct genetic information at the post-transcriptional level during development and tumorigenesis are still largely unresolved. The Bellodi lab focuses on evolutionarily conserved RNA modification machineries and noncoding RNAs in an effort to define uncharted post-transcriptional regulatory circuitries that critically impacts gene expression in stem and cancer cells. Findings from these studies will have important basic implications for different strategic areas of research including regenerative medicine, RNA biology, aging research and cancer biology. The long-term goal will be to translate these basic findings into novel therapeutic strategies for targeting key nodes of gene expression frequently altered in diseases associated with stem cell dysfunction and cancer.

Read more about the RNA and Stem Cell Biology group

List of Team Bellodi's publications


Team

(name linked to profile in Lund University research portal)

Cristian Bellodi

Principal investigator, Associate senior lecturer, Cristian [dot] Bellodi [at] med [dot] lu [dot] se

Maciej Ciesla

MD, PhD. Postdoctoral fellow, Maciej [dot] Ciesla [at] med [dot] lu [dot] se

Roberto Munita

PhD, Postdoctoral fellow, Roberto [dot] Munita [at] med [dot] lu [dot] se

Sowndarya Muthukumar

PhD, Postdoctoral fellow, Sowndarya [dot] Muthukumar [at] med [dot] lu [dot] se

Phuong Cao Thi Ngoc

PhD, Computational biologist, Phuong [dot] Cao_Thi_Ngoc [at] med [dot] lu [dot] se

Giulia Beneventi

Ph.D. Student, Giulia [dot] Beneventi [at] med [dot] lu [dot] se

Nicola Guzzi

Ph.D. Student, Nicola [dot] Guzzi [at] med [dot] lu [dot] se

Magdalena Madej

Ph.D. Student, Magdalena [dot] Madej [at] med [dot] lu [dot] se

Helena Fritz

Research Engineer, Helena [dot] Fritz [at] med [dot] lu [dot] se

Álvaro Sejas Martinez

Laboratory Assistant, alvaro [dot] sejas_martinez [dot] 6534 [at] student [dot] lu [dot] se (alvaro.sejas_martinez.6534@student.lu.se)

Page Manager:

Cristian Bellodi

Christian Bellodi

Principal Investigator
PhD, Assistant Professor
Division of Molecular Hematology
Phone: +46 46 222 30 54
Email: cristian [dot] bellodi [at] med [dot] lu [dot] se

Profile in Lund University research portal

CURRENT MAJOR GRANTS

Collaborators

Mikael Sigvardsson (Lund University)

Jonas Larsson (Lund University)

Shamit Soneji (Lund University)

Jenny Hansson (Lund University)

Göran Karlsson (Lund University)

Ana Bosch Campos (Lund University)

Göran Jönsson (Lund University)

Kristian Pietras  (Lund University)

Mar Tormo (University of Valencia, Spain)

Andrew Hsieh (Fred Hutch Cancer Research Center, USA)

Anders Lund (BRIC, Copenhagen University, Denmark)

Henrik Nielsen (Copenhagen University, Denmark)

Eva Hellström Lindberg (Karolinska Institute, Sweden)

Schragi Schwartz (Weizmann Institute, Israel)

Paolo Salomoni (DZNE Bonn, Germany)

Katja Petzold (Karolinska Institute, Sweden)

Danny Incarnato (Groningen University, Netherlands)