Our research addresses important gaps in our knowledge of how nature and nurture shape the formation of a complex and balanced immune system with important implications in life-long health and the origin of B cell cancers.
Our lab has previously identified a critical regulator of fetal lymphopoiesis, LIN28B, that endows hematopoietic stem and progenitor cells to regenerate a wider array of B cell subsets compared to their adult counterparts. Building on this work, we are currently working to peel back the layers of the adult B cell repertoire to resolve the division of labour among ontogenically distinct B cell subsets in health and disease. We are particularly interested in exploring the unique properties of neonatally induced B cell memory in the context of immune imprinting and long-term immune homeostasis. Furthermore, we seek to understand the molecular and environmental forces that shape early life immune cell output.
To this end, we have developed an extensive genetic toolkit aimed at establishing causality between developmental and immunological events disparate in time. These include 1) lineage tracing models that stratify the adult B cell compartment based on developmental origin 2) models in which critical effector functions are impaired specifically in B cells of neonatal origin 3) models with various perturbations of the fetal RNA-binding protein LIN28B. These in combination with antigen receptor repertoire analyses, immunization strategies, and cancer models provide a unique path to understand how early life derived B cells can be targeted or leveraged for improved vaccination strategies and immunotherapies.
(name linked to profile in Lund University research portal)
Principal Investigator, Joan [dot] Yuan [at] med [dot] lu [dot] se
Postdoc, elena [dot] boldrin [at] med [dot] lu [dot] serel="noopener noreferrer" target="_blank"
Postdoc, Stefano [dot] Vergani [at] med [dot] lu [dot] se
PhD student, Niklas [dot] Krausse [at] med [dot] lu [dot] se
PhD student, Selene [dot] Sodini [at] med [dot] lu [dot] se
PhD student, Hugo [dot] Akerstrand [at] med [dot] lu [dot] se
Research Engineer, Giorgia [dot] Montano [at] med [dot] lu [dot] se
Research Engineer, Karin [dot] Olsson [at] med [dot] lu [dot] se