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Laboratory of Molecular Neurogenetics

Jakobsson group

-Homepage: www.molecular-neurogenetics.lu.se

Our research

We are interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain tumors. Our current focus is to study the role of epigenetic mechanisms and microRNAs. Our technical expertise include lentiviral vectors, transgenic mice and stem cells cultures.

Aims

  • To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain.
  • To understand the functional analyses of miRNAs and their role in neural stem cells by characterizing and identifiying known and novel RNAs bound to the mouse and human RNA induced Silencing Complex in various cell types of the brain.
  • To understand how alterations in autophagy contribute to the pathophysiology of chronic neurodegenerative disorders of the CNS, such as Parkinson’s disease (PD) or Huntington’s disease (HD).
  • To develop vector-based strategies of CRISPR/Cas9-mediated gene editing in the brain for experimental and therapeutic purposes.

Impact

List of Team Jakobsson's publications


Team

(name linked to profile in Lund University research portal)

Johan Jakobsson 

Principal Investigator, Johan [dot] Jakobsson [at] med [dot] lu [dot] se    

Christopher Douse

Senior Researcher Christopher [dot] Douse [at] med [dot] lu [dot] se

Karolina Pircs 

Associate Senior Lecturer, Karolina [dot] Pircs [at] med [dot] lu [dot] se 

Diahann Atacho 

Postdoc, Diahann [dot] Atacho [at] med [dot] lu [dot] se 

Patricia Gerdes

Postdoc, Patricia [dot] Gerdes [at] med [dot] lu [dot] se

Vivien Horvath

Postdoc, vivien [dot] horvath [at] med [dot] lu [dot] se

Laura Castilla Vallmanya

Postdoc, Laura [dot] Castilla_Vallmanya [at] med [dot] lu [dot] se

Anita Adami

PhD student, Anita [dot] Adami [at] med [dot] lu [dot] se

Raquel Garza 

PhD student, Raquel [dot] Garza [at] med [dot] lu [dot] se

Ninoslav Pandiloski

PhD student, ninoslav [dot] pandiloski [at] med [dot] lu [dot] se

Ofelia Karlsson

PhD student, ofelia [dot] karlsson [at] med [dot] lu [dot] se

Ulla Jarl

Biomedical Analyst, Ulla [dot] Jarl [at] med [dot] lu [dot] se 

Jenny G Johansson 

Research Engineer, Jenny_G [dot] Johansson [at] med [dot] lu [dot] se

Marie Persson Vejgården 

Biomedical Analyst, Marie [dot] Persson_Vejgarden [at] med [dot] lu [dot] se

Yogita Sharma 

Bioinformatician, Yogita [dot] Sharma [at] med [dot] lu [dot] se 

Chandramouli Muralidharan

Project assistant, Chandramouli [dot] Muralidharan [at] med [dot] lu [dot] se

Stein Acker

Student, stein [dot] acker [dot] 1851 [at] student [dot] lu [dot] se

Georgia Christoforidou

Student, ge0067ch-s [at] student [dot] lu [dot] se

Jon Matas

Student, jo1266ma-s [at] student [dot] lu [dot] se

Meghna Vinod

Student, me1828vi-s [at] student [dot] lu [dot] se

Georgia Christoforidou

Student, ge0067ch-s [at] student [dot] lu [dot] se

Paulina Pettersson 

Project Administration Paulina [dot] Pettersson [at] med [dot] lu [dot] se 

JOHAN JAKOBSSON

 

Johan Jakobsson

Lund Stem Cell Center Director

Principal Investigator
PhD, Professor
Division of Neurobiology
Department of Experimental Medical Science
Lund Stem Cell Center
Wallenberg Neuroscience Center
BMC A11, Lund University
221 84 Lund, Sweden

Phone: + 46 46 222 42 25
Mail:Johan [dot] Jakobsson [at] med [dot] lu [dot] se

Profile in Lund University research portal