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Cell Reprogramming in Hematopoiesis and Immunity

PEREIRA group

Our research

The focus of our laboratory is to understand the molecular determinants underlying cell reprogramming and hematopoietic specification. In humans, the multiple differentiated cell states are normally stable and inherited through cell division. Under certain conditions, cell fate can, however, be modified or reversed. Cell reprogramming can be achieved experimentally in different ways, including nuclear transfer, cell fusion or expression of transcription factors. The emergent ability to directly reprogram somatic cells into desired hematopoietic cell-types is opening avenues to the discovery of new therapies for immune and blood diseases. Our approach focuses on Hematopoietic Stem Cells (HSCs) for their remarkable regenerative potential and Dendritic Cells (DCs) as key mediators of immunity.

Aims

  • To understand at the molecular level how hematopoietic cellular identities are specified during development employing cellular reprogramming
  • To use this knowledge to allow the generation of patient-specific hematopoietic and immune cells for regenerative medicine and immunotherapy

Impact

Our research will increase the understanding of the intrinsic determinants underlying hematopoietic progenitor and effector cell developmental specification. This knowledge may allow the re-creation of these unique cell identities from any human cell. Ultimately, we believe that our research will contribute to personalized hematopoietic regeneration by employing human programmed HSCs for patient-specific cell transplantation. In addition, DC reprogramming is allowing us to develop new ways to modulate the immune response. This represents a unique opportunity to merge the field of cell reprogramming and cancer immunotherapy and may result in the development of powerful new therapeutics for cancer and other diseases resulting from a dysfunctional immune system.

List of Team Pereira's publications


Team

(name linked to profile in Lund University research portal)

Filipe Pereira  

Principal investigator, PhD, Associate Professor,
filipe [dot] pereira [at] med [dot] lu [dot] se 

Cristiana Pires 

Postdoc, cristiana [dot] pires [at] med [dot] lu [dot] se 

Olga Zimmermannova 

Postdoc, olga [dot] zimmermannova [at] med [dot] lu [dot] se 

Eva Erlandsson

Research Engineer, Eva [dot] Erlandsson [at] med [dot] lu [dot] se

Rita Alves 

PhD student, rita [dot] alves [at] med [dot] lu [dot] se 

Alexandra Ferreira 

PhD student, alexandra_gabriela [dot] ferreira [at] med [dot] lu [dot] se 

Fabio Rosa 

PhD student, fabio_alexandre [dot] fiuza_rosa [at] med [dot] lu [dot] se 

Inês Caiado

PhD student, ines [dot] caiado [at] med [dot] lu [dot] se

Nejc Arh

Master student, ne1856ar-s [at] student [dot] lu [dot] se

Jennyfer Pastor Gómez

Master student, je1368pa-s [at] student [dot] lu [dot] se

Ariane Eceiza Tenreiro

Master student, ariane [dot] eceiza_tenreiro [dot] 5815 [at] student [dot] lu [dot] se

Ervin Ascic

Master student, Ervin [dot] Ascic [at] med [dot] lu [dot] se

Jakob Haider

Erasmus student, Jakob [dot] Haider [at] med [dot] lu [dot] se

Page Manager:

Filipe Pereira

Filip Pereira

Principal Investigator
PhD, Associate Professor 
Division of Molecular Medicine and Gene Therapy
Phone: +46 46 222 49 19 
Email: filipe [dot] pereira [at] med [dot] lu [dot] se 

Profle in Lund University research portal

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