Our research

Bone is a complex Organ providing structural and mechanical support of our body, but also consisting in our principal hematopoietic center. The formation of our bones is tightly and timely orchestrated, involving stages of cartilage, vasculature, bone and bone marrow establishment. My lab aims at compiling human-specific knowledge on how these tissues form, interact and regenerate at an organ scale, toward the development of innovative regenerative therapies. Precisely, we exploit Bone organogenesis as a paradigm to decipher the driving cellular and molecular mechanisms. Toward this objective, we develop cutting-edge in vitro / in vivo models offering the custom design of human skeletal tissues & organs, largely based on the exploitation of human mesenchymal stromal cell lines.

Aims

• Deciphering the cellular/molecular mechanisms involved in Bone formation/regeneration
• The design of custom biological matrices as 3D grafts for skeletal tissue regeneration
• The in vitro and in vivo development of human niches as advanced hematopoietic models

Impact

Our research will allow gaining fundamental knowledge on the mechanisms driving cartilage, bone and bone marrow establishment in a human(ized) setting. We also target broad clinical implications running from the repair of bone and cartilage defects to the “on demand” production of human blood cells for transplantation.

List of Team Bourgine's publications

Team

(name linked to profile in Lund University research portal)

Paul Bourgine

Principal Investigator, Paul [dot] Bourgine [at] med [dot] lu [dot] se   

Alejandro Garcia

Postdoc, Alejandro [dot] Garcia [at] med [dot] lu [dot] se

Ani Grigoryan

Postdoc, Ani [dot] Grigoryan [at] med [dot] lu [dot] se

Dimitra Zacharaki

Postdoc, Dimitra [dot] Zacharaki [at] med [dot] lu [dot] se

Steven Dupard 

PhD student, Steven [dot] Dupard [at] med [dot] lu [dot] se 

Sujeethkumar Prithiviraj 

PhD student, Sujeethkumar [dot] Prithiviraj [at] med [dot] lu [dot] se 

Nasim Kalantari

Master student

Tommi Glorioso

Clinical student