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RNA and Stem Cell Biology

BELLODI group

Our research

Ribonucleic acid or RNA, one of life’s indispensable molecules, governs the flow of the genetic information within cells. Our laboratory focuses on new facets of gene expression control in stem and cancer cell at a molecular, cellular and organismal level. Using hematopoiesis as a model system to study stem cell function, we combine innovative genetic models with state-of-the-art genome-wide sequencing, mechanistic and structural approaches to investigate the function of RNA epigenetic modifications, noncoding RNAs and RNA binding proteins during development and tumorigenesis.

Our mission is to uncover the molecular basis for how regulation of RNA modification and metabolism impact fundamental biological processes involved in development and cancer.

Lab vision

The mechanisms that direct genetic information at the post-transcriptional level during development and tumorigenesis are still largely unresolved. We are fascinated by evidence that evolutionarily conserved RNA modifications, noncoding RNAs and RNA binding proteins provide new regulatory layers that control gene expression in space and time. We are excited about the opportunity to understand how RNA “specialization” impacts central molecular and cellular processes underlying fundamental questions in stem cell and cancer biology.

Aims

  • To uncover the biological role of RNA epitranscriptomics in stem cells during normal and malignant hematopoiesis
  • To determine the oncogenic programs driving aberrant mRNA splicing and translation in human cancers
  • To unravel how small noncoding RNAs impact the stem cell proteome during embryogenesis and in disease

Impact

By uncovering novel regulatory pathways important for the function of stem and cancer cells, our work has broad implications within different strategic research areas including RNA and cancer biology, aging and regenerative medicine. The long-term goal is to translate our basic discoveries into novel therapeutic strategies for targeting key nodes of gene expression frequently altered in diseases associated with stem cell dysfunction and cancer.

Read more about the RNA and Stem Cell Biology group

List of Team Bellodi's publications


Team

(name linked to profile in Lund University research portal)

Cristian Bellodi

Principal Investigator, Cristian [dot] Bellodi [at] med [dot] lu [dot] se

Vaibhav Chikne

Postdoc, vaibhav [dot] chikne [at] med [dot] lu [dot] se

Maciej Ciesla

Postdoc, Maciej [dot] Ciesla [at] med [dot] lu [dot] se

Mateusz Jez

Postdoc, Mateusz [dot] Jez [at] med [dot] lu [dot] se

Roberto Munita

Postdoc, Roberto [dot] Munita [at] med [dot] lu [dot] se

Sowndarya Muthukumar

Postdoc, Sowndarya [dot] Muthukumar [at] med [dot] lu [dot] se

Phuong Cao Thi Ngoc

Computational biologist, Phuong [dot] Cao_Thi_Ngoc [at] med [dot] lu [dot] se

Giulia Beneventi

PhD student, Giulia [dot] Beneventi [at] med [dot] lu [dot] se

Magdalena Madej

PhD student, Magdalena [dot] Madej [at] med [dot] lu [dot] se

Helena Fritz

Research Engineer, Helena [dot] Fritz [at] med [dot] lu [dot] se

Hannah Finan

Student, hannah_marie [dot] finan [dot] 0038 [at] student [dot] lu [dot] se

Silvia Tucciarone

Erasmus student, silvia [dot] tucciarone [dot] 7471 [at] student [dot] lu [dot] se

 

Join us!

We are looking for talented students and postdocs to join our team. Please contact Cristian [dot] Bellodi [at] med [dot] lu [dot] se

 

CRISTIAN BELLODI

 

Cristian Bellodi

Principal Investigator
PhD, Associate Senior Lecturer
Division of Molecular Hematology
Department of Laboratory Medicine
Lund Stem Cell Center
BMC B12, Lund University
221 84 Lund, Sweden

Phone: + 46 46 222 30 54
Mail: Cristian [dot] Bellodi [at] med [dot] lu [dot] se

Profile in Lund University research portal

CURRENT MAJOR GRANTS

Collaborators

Mikael Sigvardsson (Lund University)

Jonas Larsson (Lund University)

Shamit Soneji (Lund University)

Jenny Hansson (Lund University)

Göran Karlsson (Lund University)

Ana Bosch Campos (Lund University)

Göran Jönsson (Lund University)

Kristian Pietras  (Lund University)

Mar Tormo (University of Valencia, Spain)

Andrew Hsieh (Fred Hutch Cancer Research Center, USA)

Anders Lund (BRIC, Copenhagen University, Denmark)

Henrik Nielsen (Copenhagen University, Denmark)

Eva Hellström Lindberg (Karolinska Institute, Sweden)

Schragi Schwartz (Weizmann Institute, Israel)

Paolo Salomoni (DZNE Bonn, Germany)

Katja Petzold (Karolinska Institute, Sweden)

Danny Incarnato (Groningen University, Netherlands)