The Consiglio Lab investigates how biological sex impacts human immunity using systems immunology approaches. Generally, females mount more robust immune responses than males, resulting in lower severity of infections, decreased frequency of cancer, but increased prevalence of autoimmunity. Yet, we do not fully understand the precise mechanisms that underlie such sex discrepancies. Our lab combines high throughput multiomics technologies with state-of-the-art computational methods to understand mechanisms of sex differences in human immunity.
- Immunomonitoring of human cohorts using systems immunology: We investigate the emergence and drivers of sex differences in the human immune system throughout life periods. We do this by collecting longitudinal samples of human cohorts at different stages of their life, and applying multiomics techniques and computational methods to understand sex and sex hormone modulation of human immunity.
- Mechanistic investigation of sex hormone modulation of the human immune system: Sex hormones have clear effects on immune cells; yet, we do not fully understand what immune genes, pathways and responses are modulated by sex hormones in humans. This project dives into mechanisms of sex hormone modulation of immune function in humans.
Infectious and immune-mediated diseases constitute a high economic and health burden worldwide, which has been recently exemplified by the COVID-19 pandemic. The most common treatment for respiratory infections is supportive care rather than immune modulation. Thus, there is currently an urgent need for the development of immunotherapies against infectious agents to reduce infection-associated death and morbidity. Uncovering the mechanisms underlying sexual dimorphism in immunity is essential to understanding both infectious and immune-mediated diseases, as well as to better design, optimize and individualize immunomodulatory therapies.
(name linked to profile in Lund University research portal)
Principal Investigator, camila [dot] consiglio [at] med [dot] lu [dot] se
PhD, Assistant Professor
Department of Laboratory Medicine
BMC B12, Lund University
221 84 Lund, Sweden
Phone: +46 046-2228132
Mail: camila [dot] consiglio [at] med [dot] lu [dot] se
Profile in Lund University research portal
CURRENT MAJOR GRANTS:
- 2022 DDLS Fellowship: for a tenure-track position in Infection Biology and Epidemiology (17M SEK, 5 years) at Lund University supported by the SciLifeLab & Wallenberg Data Driven Life Science Program KAW 2020.0239 (2023-2027).
- 2021 Michelson Prize: (USD 150,000) awarded by the Michelson Medical Research Foundation and the Human Vaccines Project to investigate the effects of testosterone on the human immune system (2022).
- Marie Skłodowska-Curie Individual Fellowship: (191,852.16€) awarded by the European Commission to investigate the roles of sex hormones in human antiviral immunity in the laboratory of Dr. Petter Brodin – Karolinska Institutet, Stockholm, Sweden (2021-2023).
- KI Research FoundationGrant: (199,800 SEK) to investigate the roles of sex hormones in the human immune system – Karolinska Institutet, Stockholm, Sweden (2020-2021).