Hematopoietic Stem Cell Development Laboratory
Hematopoietic stem cells (HSCs) are rare cells in the body that possess the ability to generate vast numbers of a multitude of specialised blood cell types required for our survival. HSCs are first generated in the early embryo and undergo a series of maturation processes that ultimately give rise to their key adult features of self-renewal, blood cell generation, and transplant capability. Our laboratory uses embryonic-like stem cells, termed induced pluripotent stem (iPS) cells, as the starting material in our culture systems to generate de novo hematopoietic stem and progenitor cells.
Research areas include:
- Metabolic regulation in HSC development
- Mitigation of cellular stress in HSC development culture systems
- The molecular processes in endothelial-to-hematopoietic transition
- Neurotransmitter signalling in HSC development
- Cell Therapy modelling, correcting human disease models using iPS derived blood cells
Our principle goal is to understand the molecular processes involved in hematopoietic stem cell (HSC) development and recapitulate these processes in cell culture systems of pluripotent stem cells.
With this understanding, we ultimately aim to provide an unlimited source of patient matched HSCs patients with blood disorders and malignancies.
We aim to be able to provide these cells to patients in need through academic/industrial partners within the next 7-10 years.
Hematopoietic stem cell (HSC) transplantation is a life-saving procedure for tens of thousands of patients each year for the treatment of hematological diseases and malignancies. Unfortunately, the limited availability of suitably matched donors of HSCs, leaves a significant fraction of patients (up to 30%) unable to undergo transplantation. The ability to generate de novo HSCs from an unlimited source of cells, such as from a patient derived iPS cells, would enable the generation of an unlimited supply of matched transplantable HSCs for therapeutic purposes.
Join us: we are on the lookout for two talented postdoc level researchers. Please contact niels-bjarne [dot] woods [at] med [dot] lu [dot] se and provide your CV and a cover letter describing your research background and interests.
(name linked to profile in Lund University research portal)
Principal Investigator, Niels-Bjarne [dot] Woods [at] med [dot] lu [dot] se
Postdoc, Leal [dot] Oburoglu [at] med [dot] lu [dot] se
Researcher, Roger [dot] Ronn [at] med [dot] lu [dot] se
Staff Scientist, Xiaojie [dot] Xian [at] med [dot] lu [dot] se
Division of Molecular Medicine and Gene Therapy
Phone: +46 46 222 37 62
Email: niels-bjarne [dot] woods [at] med [dot] lu [dot] se