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Stem Cell Laboratory for CNS Disease Modeling

Roybon Group

Homepage: https://www.ipsc-cns-disease.lu.se/

 

Our research

Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. Our work focuses on the interactions between glia and neurons. We are constantly developing new and robust human stem cell-based models which we utilize to understand cell autonomous and non-cell autonomous processes that lead to neuronal damage.

 

Aims

  • By generating iPSCs from patients suffering familial and sporadic forms of the diseases, we aim to elucidate causative mechanisms leading to neural cell dysfunction, and neurodegeneration

 

Impact

Our cutting-edge approach will allow for the identification of new molecular targets, which could be used for the development of new diagnostic tools for early diagnosis, as well as for the stratification and recruitment of patients for future clinical trials.

List of Team Roybon's publications


Team

(name linked to profile in Lund University research portal)

Laurent Roybon 

Principal Investigator, Laurent [dot] Roybon [at] med [dot] lu [dot] se

Yuriy Pomeshchik 

Postdoc, Yuriy [dot] Pomeshchik [at] med [dot] lu [dot] se

Kaspar Russ 

Postdoc, Kaspar [dot] Russ [at] med [dot] lu [dot] se

Ekaterina Savchenko 

Postdoc, Ekaterina [dot] Savchenko [at] med [dot] lu [dot] se