The broad interest of our group lies in understanding the molecular differences between fetal and adult hematopoiesis. Proteins are the machinery of the cell, responsible for executing the functions essential for cells to operate, survive, differentiate and divide. Increasing evidence emphasises that a substantial variance of protein expression is conveyed at the levels of protein synthesis and degradation, and that post-transcriptional control of gene expression plays a critical role in multiple aspects of cell biology, including coordination of cellular processes and rapid alteration of cellular phenotype. Importantly, the proteomic make-up of blood stem cells and progenitors can regulate their cell fate and susceptibility to initiation as well as progression of leukemia.
By using in-depth mass spectrometry-based quantitative proteomics to monitor protein levels in a comprehensive and quantitative manner, our research aims to:
- define the fetal- and adult-specific proteomic programs that regulate normal and malignant hematopoiesis
- use this knowledge to perturb proteins of ontogeny-specific leukemic features
Our work will advance the understanding of ontogenic influence on hematopoiesis and create a basis for the identification of novel age-tailored therapeutic approaches for treatment in young and old leukemic patients.
(name linked to profile in Lund University research portal)
Principal investigor, PhD, Jenny [dot] Hansson [at] med [dot] lu [dot] se
PhD, Postdoctoral Fellow, sudip [dot] ghosh [at] med [dot] lu [dot] se
PhD, Postdoctoral Fellow, Kristyna [dot] Pimkova [at] med [dot] lu [dot] se
PhD Student, Maria [dot] Jassinskaja [at] med [dot] lu [dot] se